Journal
HEPATOLOGY
Volume 56, Issue 6, Pages 2404-2411Publisher
WILEY
DOI: 10.1002/hep.25929
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Funding
- Italian Association for Cancer Research (Milan, Italy) [10416]
- Italian Ministry of Health and Education (Finanziamenti per la Ricerca di Base) [IDEAS RBID08C9N7]
- Italian Ministry of Health [GR-2008-1143546]
- European Community [202272]
- Cariplo Fundation Milan, University of Bari, Bari, Italy [ORBA 08WEZJ, 07X7Q1, 06BXVC, IDEA GRBA0802SJ]
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Fibroblast growth factors (FGFs) 15/19 and 21 belong to the FGF endocrine subfamily. They present the intriguing characteristic to be transcribed and secreted in certain tissues and to act as hormones. The insulin-mimetic properties of FGF21 and the regulatory role of FGF15/19 in bile acid and glucose homeostasis endorse these hormones as druggable targets in metabolic disorders. Here, we present details on discoveries, identification, transcriptional regulation, and mechanism of actions of FGF15/19 and FGF21 with a critical perspective view on their putative role as metabolic integrators in the liver. (HEPATOLOGY 2012;56:2404-2411)
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