Journal
HEPATOLOGY
Volume 51, Issue 4, Pages 1438-1444Publisher
WILEY
DOI: 10.1002/hep.23405
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Categories
Funding
- National Institutes of Health [R01 DK58123, R01 DK070849]
- Fred and Suzanne Biesecker Pediatric Liver Center
- Yale Liver Center [DK34989]
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Portal fibroblasts are an important yet often overlooked nonparenchymal cell population in the liver. They are distinct from hepatic stellate cells, yet like stellate cells differentiate in the setting of chronic injury to fibrogenic myofibroblasts, playing an important role in collagen production in the fibrotic liver. Portal fibroblasts (PFs) are located adjacent to bile duct epithelia and thus play a particularly significant role in biliary fibrosis. New data suggest that they may also have key functions independent of fibrogenesis. This review addresses the definition and characteristics of PFs as well as their signaling pathways, interactions with the biliary epithelium, and contributions to liver pathobiology. Conclusion: PFs are an important and multifunctional nonparenchymal cell population in need of further study. (HEPATOLOGY 2010;51:1438-1444.)
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