Journal
HEPATOLOGY
Volume 48, Issue 2, Pages 670-678Publisher
WILEY-BLACKWELL
DOI: 10.1002/hep.22399
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Funding
- NIDDK NIH HHS [R01 DK068450-04, R01 DK061510, P30 DK026743, R01 DK068450, P30 DK026743-25S1] Funding Source: Medline
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Obesity is an inflammatory disorder characterized by heightened activity of the innate immune system. Innate immune activation is central to the development of obesity-related insulin resistance; it also plays an important role in obesity-related tissue damage, such as that seen in atherosclerosis. Recent research has implicated the innate immune system in the pathophysiology of obesity-related liver disease. This review summarizes how innate immune processes, occurring both within and outside the liver, cause not only insulin resistance but also end-organ damage in the form of nonalcoholic fatty liver disease.
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