Journal
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
Volume 12, Issue 2, Pages 149-153Publisher
ZHEJIANG UNIV SCH MEDICINE
DOI: 10.1016/S1499-3872(13)60024-7
Keywords
hepatitis B virus; recurrence; lamivudine; hepatitis B immunoglobulin; liver transplantation
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Funding
- National Natural Science Foundation of China [30872556]
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BACKGROUND: Lamivudine and hepatitis B immunoglobulin (HBIG) are widely used to treat patients with hepatitis B recurrence after liver transplantation. However, the outcomes are inconclusive. The present study was undertaken to evaluate the effect of combined therapy on patients with hepatitis B recurrence after liver transplantation. METHODS: Twenty-two patients with hepatitis B recurrence after liver transplantation from August 2000 to October 2011 were enrolled in this study. Of these patients, 16 received lamivudine plus HBIG (combination therapy group) and 6 were treated with lamivudine alone (lamivudine-treated group). The clinical features were matched in the two groups. HBV recurrence parameters, HBsAg clearance rate, patient survival rate, and survival time were compared. RESULTS: The average time of follow-up was 47.2 months (range 13-99). Significant difference was noted in the HBsAg clearance rate in the lamivudine-treated and combination therapy groups (50% vs 93.8%, P<0.05). There was no significant difference in the time of HBV recurrence, patient survival rate and survival time between lamivudine-treated and combination therapy groups (P>0.05). CONCLUSION: Compared with lamivudine monotherapy, combination therapy significantly increased the HBsAg clearance rate in patients with HBV recurrence after liver transplantation. (Hepatobiliary Pancreat Dis Int 2013;12:149-153)
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