Journal
HEPATITIS MONTHLY
Volume 14, Issue 8, Pages -Publisher
KOWSAR PUBL
DOI: 10.5812/hepatmon.18672
Keywords
Hepatocellular Carcinoma; MicroRNAs; Regulation; Therapeutic Targets
Categories
Funding
- National Natural Science Foundation of China [31302118]
- National High Technology Research and Development Program of China (863 Program) [2011AA10A211-1]
- High-level Technological Talent Program of Gansu Province [1013JHTA008]
- International Atomic Energy Agency [16025/R0]
- China Agriculture Research System [CARS-39]
Ask authors/readers for more resources
Context: MicroRNAs (miRNAs) are small, noncoding RNAs that play an important role in posttranscriptionalgene regulation and function as negative gene regulators. They are an abundant class of RNA, each of which can control hundreds of gene targets and regulate diverse biological processes such as hematopoiesis, organogenesis, apoptosis and cell proliferation. Aberrant miRNA expression contributes to tumorigenesis and cancer progression. Evidence Acquisition: In this study we provided a summarized review of the most important new data available on hepatocellular carcinoma (HCC)-associated miRNAs. The data were collected through searching the related keywords and were categorized and summarized in different sections. Results: Researchers have reported that miRNAs can repress the expression of important cancer-related genes and might be helpful in the diagnosis and treatment of cancer. During the past two decades, numerous studies have shown that miRNAs play an essential role in inhibiting HCC via several different pathways. Deregulated miRNAs may contribute to carcinogenesis, indicating that miRNAs can act as tumor suppressors and oncogenes. Conclusions: In this mini review, we highlight current findings and discuss recent work to determine the contribution of miRNA expression to the maintenance and growth of HCC, thereby providing a significant source of hope that miRNAs could serve as therapeutic targets.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available