Journal
HEMOGLOBIN
Volume 34, Issue 6, Pages 582-586Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/03630269.2010.526914
Keywords
Elongated alpha-globin chain; Hb Constant Spring (Hb CS); Hb Pakse; Dot-blot hybridization; Gene frequency
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Funding
- National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand
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Hb Constant Spring [Hb CS, alpha 142(H19) Term] and Hb Pakse [alpha 142(H19) Term] occur from the mutation in the termination codon of the alpha 2-globin gene, TAA > CAA (-> Gln) and TAA > TAT (-> Tyr), respectively. They are the most common nondeletional alpha-thalassemia (alpha-thal) variants causing Hb H disease in Southeast Asia. In this study, 587 cord blood samples were screened for the Hb CS and Hb Pakse mutations by a dot-blot hybridization technique using oligonucleotide probes specific for each mutation. The results showed that the prevalence of Hb CS and Hb Pakse in Central Thailand are 5.80 and 0.51%, respectively, which is in concordance with the results from previous studies.
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