Journal
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
Volume 23, Issue 6, Pages 1177-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2009.08.007
Keywords
Autoimmunity; Platelets; Thrombocytopenia; T lymphocytes; Immune tolerance
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In the last 20 years, many publications have shed new light on the complex immunopathogenesis of immune thrombocytopenic purpura. They are associated with 3 interrelated areas of environmental autoimmunity, for example, infectious influences, antigen-presenting cell (APC) function, and T-cell abnormalities, particularly tolerance induction. This article highlights the recent literature and argues that infectious agents and platelets can significantly modulate APCs, which create an environment that dysregulates autoreactive T cells, leading to the production of autoantibodies.
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