Journal
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
Volume 23, Issue 2, Pages 283-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2009.01.010
Keywords
Anemia; Inherited; Erythropoiesis; Dyserythropoiesis; Iron overload
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Funding
- Berrow Foundation (Switzerland)
- Lincoln College, University of Oxford (UK)
- Valeria Rossi di Montelera Trust (Switzerland)
- Medical Research Council [MC_U137961145] Funding Source: researchfish
- MRC [MC_U137961145] Funding Source: UKRI
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The congenital dyserythropoietic anemias (CDAs) are a heterogeneous group of hereditary disorders that seem to be restricted to the erythroid lineage. They are characterized by morphologic abnormalities of erythroid precursors in the bone marrow, resulting in ineffective erythropoiesis and a suboptimal reticulocyte response. As with many rare disorders, cases of CDA are often misdiagnosed, which may lead to inappropriate management. In this review, the authors highlight the relevant clinical data together with recent molecular advances that should aid decision making in diagnosis and patient management.
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