Journal
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
Volume 22, Issue 6, Pages 1099-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2008.08.007
Keywords
Head and neck neoplasms; Cancer; Review; Molecular biology; Pathway
Categories
Funding
- NCI NIH HHS [L30 CA104183, L30 CA104183-01, L30 CA104183-02] Funding Source: Medline
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Patients present with a differential baseline risk of cancer based on normal and expected variations in genes associated with cancer. The baseline risk of developing cancer is acted on throughout life as the genome of different cells interacts with the environment in the form of exposures (eg, toxins, infections). As genetic damage is incurred throughout a lifetime (directly to DNA sequences or to the epigenome), events are set in motion to progressively disrupt normal cellular pathways toward tumorigenesis. This article attempts to characterize broad categories of genetic aberrations and pathways in a manner that might be useful for the clinician to understand the risk of developing cancer, the pathways that are disrupted, and the potential for molecular-based diagnostics.
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