Journal
HELVETICA CHIMICA ACTA
Volume 97, Issue 5, Pages 664-668Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.201300248
Keywords
Penicillium; Fungi; Polyketides; Palitantin; Acetylcholinesterase (AchE) inhibitory activity; X-Ray crystallography
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Funding
- National Natural Science Foundation of China [20972197, 41276146, 21102020]
- 863 Foundation of China [2011AA09070201]
- Science & Technology Plan Project of Guangdong Province of China [2010B030600004, 2011A080403006]
- Fundamental Research Funds for the Central Universities of China [11lgjc01]
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Two polyketides were isolated from the mangrove endophytic fungus, Penicillium sp. sk14JW2P, and one derivative with a modified structure. The structures were elucidated by spectroscopic analyses, the structure of the compound 1 was further confirmed by single-crystal X-ray diffraction, and its absolute configuration was determined. Compound 1 and 2 showed acetylcholinesterase (AchE) inhibitory activities with IC50 values of 12 +/- 0.3 and 79 +/- 2nM, respectively.
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