Journal
HELVETICA CHIMICA ACTA
Volume 96, Issue 4, Pages 682-687Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.201200433
Keywords
Sargassum pallidium; Penicillium chrysogenum; Chrysotriazoles A and B; Cytotoxic activity
Categories
Funding
- Ministry of Science and Technology [2010CB833802]
- Natural Science Foundation of China [30910103914, 30970293]
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Two new triazoles, chrysotriazoles A and B (1 and 2, resp.), along with two known quinazolinones, 3 and 4, two known 2-(4-hydroxyphenyl)acetamides, 5 and 6, and two known N-(4-hydroxystyryl)formamides, 7 and 8, were isolated and identified from the culture extract of Penicillium chrysogenum EN-118, an endophytic fungus obtained from the marine brown alga Sargassum pallidium. The structures of the isolated compounds were elucidated by NMR-spectroscopic analysis, and that of compound 1 was confirmed by X-ray crystallographic analysis of its p-bromobenzoate derivative. Compounds 4, 5, and 7 showed moderate cytotoxicities against Du145, A-549, and HeLa cell lines.
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