Journal
HELVETICA CHIMICA ACTA
Volume 96, Issue 3, Pages 414-418Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.201200168
Keywords
Spiro[3H-indole-3; 2-thiazolidine]-2; 4(1H)-diones; Multicomponent reactions; Ionic liquids
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Funding
- UGC
- CSIR, New Delhi, India
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A facile one-pot, three-component protocol for the synthesis of novel spiro[3H-indole-3,2-thiazolidine]-2,4(1H)-diones by condensing 1H-indole-2,3-diones, 4H-1,2,4-triazol-4-amine and 2-sulfanylpropanoic acid in [bmim]PF6 (1-butyl-3-methyl-1H-imidazolium hexafluorophosphate) as a recyclable ionic-liquid solvent gave good to excellent yields in the absence of any catalyst (Scheme1 and Table2). The advantages of this protocol over conventional methods are the mild reaction conditions, the high product yields, a shorter reaction time, as well as the eco-friendly conditions.
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