Journal
HELVETICA CHIMICA ACTA
Volume 95, Issue 1, Pages 157-162Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.201100275
Keywords
Eutypella scoparia; Farnesanes; Sesquiterpenes; Acoranes; Marine fungi; Fungi
Categories
Funding
- Chinese Academy of Sciences [KSCX2-EW-G-12]
- Guangdong Provincial Project for Science and Technology [2010B030600010]
- Guangdong Academy of Sciences Foundation for Outstanding Young Scientists
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A new monocyclofarnesane-type sesquiterpene, 3,7,10-trihydroxy-6,11-cyclofarnes-1-ene (1), and a new acorane-type sesquiterpene, 8-(hydroxymethyl)-1-(2-hydroxy-1-methylethyl)-4-methylspiro[4.5]dec-8-en-7-ol (2), were isolated from the culture of Eutypella scoparia FS26 from the South China Sea, along with three known terpenes, 35. The structures of these compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature reports. The isolated compounds 15 were evaluated for their cytotoxic activities against the SF-268, MCF-7, and NCI-H460 tumor cell lines.
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