Journal
HELVETICA CHIMICA ACTA
Volume 95, Issue 2, Pages 235-239Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.201100278
Keywords
Sarcophyton trocheliophorum; Cembranoids; Yalongenes A and B; Cytoprotective activity; Soft corals
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Funding
- National Science & Technology Major Project [2009ZX09301-001]
- National Marine 863 Project [2011AA09070102]
- Natural Science Foundation of China [21072204, 30730108, 21021063]
- NSFC-TRF [20911140471]
- STCSM between SIMM/China and ICB/Italy [10540702900]
- Hungarian-Chinese Intergovernmental S&T Cooperation Programme
- EU 7th Framework Programme-IRSES Project
- SIMM-SKLDR [KSCX2-YW-R-18, SIMM1105KF-04, SIMM1106KF-11]
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Two new cembranoids, yalongenes A (1) and B (2), were isolated from the South China Sea soft coral Sarcophyton trocheliophorum Marenzeller. Their structures were elucidated by detailed spectroscopic analysis (IR, MS, and NMR) and by comparison with a related model compound. Yalongenes 1 and 2 were evaluated for their cytoprotective effects on SH-SY5Y cell injury induced by H2O2 in vitro, and the result showed that only compound 1 had a significant cytoprotective activity at the concentration of 1 mu M.
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