Two New Cyclic Pentapeptides from the Marine-Derived Fungus Aspergillus versicolor

Two new cyclic pentapeptides, named versicotides A (1) and B (2), were obtained from a marine-derived fungus strain ZLN-60, identified as Aspergillus versicolor. Their structures were established on the basis of chemical and spectroscopic evidence. Versicotides are new cyclic pentapeptides which contain an L-alanine residue, two anthranilic acid (=2-aminobenzoic acid) residues, and two N-methyl-L-alanine residues. Antitumor activities were evaluated by the SRB and MTT methods.