Journal
HELVETICA CHIMICA ACTA
Volume 93, Issue 2, Pages 361-374Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.200900194
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The seven new triterpenoid saponins 1-7 were isolated from the roots of Gypsophila paniculata L. Their structures were established by 1D- and 2D-NMR techniques, HR-MS, and acid hydrolysis. The isolated compounds include 3,28-O-bidesmosides with or without a 4-methoxycinnamoyl group (see 1 vs. 2 and 3), and 3-O-monoglucosides 4-7. All isolated saponins 1-7 and their aglycones were evaluated for their alpha-glucosidase inhibition activity. Compound 1 showed inhibitor activity against yeast alpha-glucosidase with an IC50 value of 100.9 +/- 3.3 mu M, whereas compounds 2-7 were inactive.
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