Ceramides and Cerebrosides from Ligusticum chuanxiong HORT.

Two new ceramides, (2R)-2-hydroxy-N-[(2S,3S,4R,8E)-1,3,4-trihydroxypentadec-8-en-2-yl]heptacosanamide (1) and (2R)-2-hydroxy-N-{(3S,4S,5S)-4-hydroxy-5-[(4E)-undec-4-en-1-yl]tetrahydrofuran-3- yl}heptacosanamide (2), were isolated from the aerial parts of Ligusticum chuanxiong, along with one known ceramide. (2R)-2-hydroxy-N-[(2S,3S,4R,8E)-1,3,4-trihydroxyicos-8-en-2-yl]tetracosanamide (3), and two known cerebrosides, (2R)-N-[(2S,3R,4E,8E)-1-(beta-D-glucopyranosyloxy)-3,4-dihydroxyoctadec-8-en-2-yl]-2-hydroxyhexadecanamide (5). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR, as well as HR-ESI-MS experiments.