Journal
HELVETICA CHIMICA ACTA
Volume 92, Issue 7, Pages 1419-1427Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.200800448
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An extensive study of metabolites present in Excoecaria agallocha LINN. led to the isolation of three new ent-labdane-type diterpenoids, named agallochaexcoerins A-C (1-3). besides three known compounds. The skeleton present in compound I is rather unusual, containing of a seven-membered lactone. The structures were elucidated on the basis of spectroscopic studies and comparison with known related compounds. The isolated compounds 1-6 were not active against Raw 264.7 (macrophage-like), K 562 (leukemia), and COLO 205 (colon) human carcinoma cell lines.
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