Journal
HELVETICA CHIMICA ACTA
Volume 92, Issue 7, Pages 1341-1348Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.200800447
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Funding
- National Marine 863 Projects [2006AA09Z447, 2006AA09Z412, 2007AA09Z402]
- Natural Science Foundation of China [30730108, 20721003, 20772136]
- STCSM Project [07XD14036]
- Syngenta-SIMM-PhD
- CAS [KSCX2-YW-R-18]
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Two new cembrane diterpenes, sinulaparvalides A and B (1 and 2, resp.), which contain an intriguing seven-membered lactone moiety, along with the four known related cembranoids 3-6, were isolated from the Hainan soft coral Sinularia parva. The structures of compounds I and 2 were established by spectroscopic methods, mainly on the basis of 2D-NMR techniques, and were confirmed by single-crystal X-ray diffraction analysis. The in vitro cytotoxic activities of these compounds were tested on human colon carcinoma (HCT-116), human promyelocytic leukemia (HL-60), and human lung carcinoma (A-549) tumor cell lines.
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