Journal
HELVETICA CHIMICA ACTA
Volume 92, Issue 8, Pages 1538-1544Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.200800455
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Funding
- Chinese National Natural Science Fund [30772640]
- Shandong Province [Z2006C13]
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Five new cytochalasins, Z(16)-Z(20) (1-5), and three known ones, 6-8, were isolated from Aspergillus flavipes, an endophytic fungus associated with Acanthus ilicifolius. Their structures were elucidated on the basis of comprehensive spectral analysis. Cytochalasin Z(17) (2) and rosellichalasin (8) showed cytotoxic activities against A-549 cell lines with IC50 values of 5.6 and 7.9 mu M, respectively.
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