Two new 2-phenylethyl alcohol derivatives and one new lignan derivative from the root of Ilex pubescens

The phytochemical investigation of the methanolic extract of the root of Ilex pubescens HoOK. et ARN. furnished six compounds including three new compounds, ilexin A (1), ilexin B (2), and ilexin C (3), besides vanillic acid, vanillin, and caffeic acid. Compounds 1 and 2 were identified as 2-phenylethyl alcohol derivatives, while compound 3 is a lignan derivative. The structures of these compounds have been elucidated by the combination of the analysis of NMR and MS data, CD spectra, and chemical evidences.