Baimantuoluolines D-F, three new withanolides from the flower of Datura metel L.

Three new withanolide compounds, named baimantuoluolines D-F, along with three known withanolides and a lignan were isolated from the flower of Datura metel L., the parts effective against psoriasis. The structures of the new compounds were elucidated as (5 alpha,6 beta,12 beta,20R,22R,24R,25S)-21,24-epoxy-5,6,12-trihydroxy-27-methoxy-1-oxowith-2-enolide (1), (5 alpha,6 beta,12 beta,20R,22R,24R,25S)-21,24-epoxy-5,6,12,27-tetrahydroxy-1-oxowith-2-enolide (2), and (5 alpha,6 beta,12 beta,22R)-5,6,12,21-tetrahydroxy-1-oxowith-24-enolide(3) on the basis of physicochemical evidence.