Journal
HELICOBACTER
Volume 16, Issue -, Pages 53-58Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1523-5378.2011.00881.x
Keywords
Peptic ulcer disease; resistance; compliance; first-line; second-line; susceptibility testing
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This article reviews the literature published pertaining to Helicobacter pylori eradication over the last year. The general perception among clinicians and academics engaged in research on H. pylori has been that eradication rates for first-line therapies are falling, although some data published this year have cast doubt on this. The studies published this year have therefore focussed on developing alternative strategies for the first-line eradication of H. pylori. In this regard, clear evidence now exists that both levofloxacin and bismuth are viable options for first-line therapy. The sequential and concomitant regimes have also been studied in new settings and may have a role in future algorithms also. In addition, data have emerged that the probiotic Saccharomyces boulardii may be a useful adjunct to antibiotic therapy. Other studies promote individualized therapies based on host polymor-phisms, age, and other such demographic factors.
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