Journal
HEART FAILURE REVIEWS
Volume 16, Issue 4, Pages 425-435Publisher
SPRINGER
DOI: 10.1007/s10741-011-9234-6
Keywords
Resveratrol; Red wine; White wine; Cardioprotection; Longevity genes; Anti-aging; SIRT; FoxO; PBEF
Categories
Funding
- NHLBI NIH HHS [HL 34360, HL33889, HL22559] Funding Source: Medline
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Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.
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