Journal
HEART AND VESSELS
Volume 30, Issue 4, Pages 498-502Publisher
SPRINGER
DOI: 10.1007/s00380-014-0507-6
Keywords
Aneurysm; Antibody; Arrhythmia; Bacteria; Periodontal disease
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [25870198]
- Mitsui Life Social Welfare Foundation
- Daiwa Security Health Foundation
- Mitsui Sumitomo Marine Welfare Foundation
- Institute of Geriatric Dentistry Foundation
- Institute of St. Luka Life Science Foundation
- Health Welfare Foundation
- Taiyo Life Welfare Foundation
- 8020 Foundation
- Pfizer Health Research Foundation
- Grants-in-Aid for Scientific Research [25870198, 26670395] Funding Source: KAKEN
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Although there is a link between periodontitis and cardiovascular disease (CVD), the influence of periodontitis on CVD is unclear. The aim of this study was to assess the relationship between periodontal bacterial burden and CVD. We studied 142 patients with tachyarrhythmia (TA) and 25 patients with abdominal aortic aneurysm (AAA). We examined periodontitis and the presence of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Prevotella intermedia in the patients' saliva and subgingival plaque using PCR. We also measured serum antibody titers against the pathogens using ELISA. We found that the patients with AAA had fewer remaining teeth (14.6 +/- A 2.0 vs. 20.9 +/- A 0.7, P < 0.05) and deeper pocket depth (3.01 +/- A 0.26 vs. 2.52 +/- A 0.05 mm, P < 0.05) compared to the TA patients. The existence of each periodontal bacterium in their saliva or subgingival plaque and serum antibody titers was comparable between the two groups. Periodontitis may have a larger affect on aneurysm progression compared to arrhythmia.
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