Journal
HEART & LUNG
Volume 43, Issue 6, Pages 534-540Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.hrtlng.2014.05.010
Keywords
Autonomic dysfunction; Heart rate variability; Idiopathic pulmonary arterial hypertension; Pulmonary arterial pressure; Ventricular arrhythmia
Funding
- Taichung Veterans General Hospital [TCVGH-993101B, TCVGH-1003105C, TCVGH -1013105C]
- Yen Tjing Lin Medical Foundation, Taiwan, R.O.C. [CI-97-12, CI-98-15, CI-99-13]
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Objective: This aim of this study was to correlate heart rate variability (HRV) parameters to pulmonary arterial pressure (PAP) in patients with purely idiopathic pulmonary arterial hypertension (IPAH). Background: HRV is decreased in patients with PAH. Whether HRV indices can be used to assess PAP in IPAH patients remains unclear. Methods: HRV parameters obtained by 24-h ECG were evaluated in 26 IPAH patients and 51 controls. Results: Time-domain HRV parameters (SDNN, p < 0.0001; SDANN, p < 0.0001; RMSSD, p = 0.006) were lower in IPAH patients. Frequency-domain indices (high-frequency power, HFP,p = 0.001; low-frequency power, LFP, p = 0.003; total power, TP, p = 0.001) were also decreased in IPAH patients. In IPAH patients, RMSSD (p = 0.001), HFP (p = 0.015), and LFP (p = 0.027) were significantly correlated with PAR IPAH patients had longer QTc intervals (p < 0.0001) and more premature ventricular contractions (p < 0.0001) than controls. Conclusions: IPAH is associated with autonomic dysfunction. RMSSD, HFP, and LFP may be used as a supplemental tool to assess PAP in IPAH patients. IPAH patients with autonomic dysfunction are at high risk for ventricular arrhythmia. (C) 2014 Elsevier Inc. All rights reserved.
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