Journal
LAB ON A CHIP
Volume 15, Issue 18, Pages 3760-3765Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5lc00722d
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Funding
- Natural Sciences and Engineering Research Council of Canada
- Banting postdoctoral fellowship programs
- US Department of Education GAANN
- NIH MBSTP [NIH T32 EB005582]
- NSF [CBET 1149401]
- NIH [CA 170198, AI116482]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1149401] Funding Source: National Science Foundation
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We designed a fabrication technique able to replicate microstructures in soft silicone materials (E < 1 kPa). Sugar-based 'hard candy' recipes from the confectionery industry were modified to be compatible with silicone processing conditions, and used as templates for replica molding. Microstructures fabricated in soft silicones can then be easily released by dissolving the template in water. We anticipate that this technique will be of particular importance in replicating physiologically soft, microstructured environments for cell culture, and demonstrate a first application in which intrinsically soft microstructures are used to measure forces generated by fibroblast-laden contractile tissues.
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