Journal
LAB ON A CHIP
Volume 15, Issue 11, Pages 2364-2378Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5lc00234f
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Funding
- University of Wisconsin-Madison Carbone Cancer Center [NIH P30 CA014520]
- Bill and Melinda Gates Foundation
- National Human Genome Research Institute through the Genomic Science Training Program [5T32HG002760]
- National Institutes of Health
- Natural Sciences and Engineering Research Council of Canada
- Grand Challenges Canada
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This tutorial review offers protocols, tips, insight, and considerations for practitioners interested in using micromilling to create microfluidic devices. The objective is to provide a potential user with information to guide them on whether micromilling would fill a specific need within their overall fabrication strategy. Comparisons are made between micromilling and other common fabrication methods for plastics in terms of technical capabilities and cost. The main discussion focuses on how-to aspects of micromilling, to enable a user to select proper equipment and tools, and obtain usable microfluidic parts with minimal start-up time and effort. The supplementary information provides more extensive discussion on CNC mill setup, alignment, and programming. We aim to reach an audience with minimal prior experience in milling, but with strong interests in fabrication of microfluidic devices.
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