Journal
LAB ON A CHIP
Volume 15, Issue 8, Pages 1835-1841Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4lc01483a
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Funding
- Brazilian agency FAPESP [2013/14262-7, 2013/04663-4]
- Brazilian agency CNPq [306106/2013-2, 478525/2013-3]
- Brazilian agency INEO
- Brazilian agency Nanomedicine Networks (NanoBio-Net and NanoBioMed-Brazil, CAPES)
- FAPESP [2011/23362-0]
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Magnetite decorated with gold nanoparticles (Fe3O4-AuNPs) is a ferrimagnetic material with unprecedented applications in immunosensors, as a contrast agent for imaging diagnosis, and for the photothermal ablation of tumor cells. Here, we show the preparation of controlled amounts of Fe3O4-AuNPs without organic solvents, surfactants, or heat treatment. For this, we have developed a customized natural-rubber-based microfluidic device (NRMD) as a flexible lab-on-a-chip for the decoration of Fe3O4 with AuNPs. With a novel NRMD configuration, monodisperse Fe3O4-NPs (phi = 10 nm) decorated with AuNPs (phi = 4 nm) were readily obtained. The AuNPs were homogenous in terms of their size and their distribution on the Fe3O4-NP surfaces. Furthermore, the lab-on-a-chip was projected with an internal system for magnetic separation, an innovation in terms of aqueous/carrier phase separation. Finally, the nanomaterials produced with this NRMD are free of organic solvents and surfactants, allowing them to be used directly for medical applications.
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