Journal
LAB ON A CHIP
Volume 15, Issue 7, Pages 1689-1696Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5lc00095e
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Funding
- NSF [CBET-1438779]
- NSF Graduate Research Fellowship [DGE-1144085]
- Dow Chemical Company through the Dow Materials Institute at the University of California, Santa Barbara (UCSB)
- NSF Materials Research Science and Engineering Centers Program [DMR 1121053]
- UCSB nanofabrication facility, NSF-funded National Nanotechnology Infrastructure Network
- Directorate For Engineering [1438779] Funding Source: National Science Foundation
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Recent advancements in microfluidic technology have allowed for the generation and control of complex chemical gradients; however, few general techniques can measure these spatio-temporal concentration profiles without fluorescent labeling. Here we describe a Fabry-Perot interferometric technique, capable of measuring concentration profiles in situ, without any chemical label, by tracking Fringes of Equal Chromatic Order (FECO). The technique has a sensitivity of 10(-5) RIU, which can be used to track local solute changes of similar to 0.05% (w/w). The technique is spatially resolved (1 mu m) and easily measures evolving concentration fields with similar to 20 Hz rate. Here, we demonstrate by measuring the binary diffusion coefficients of various solutes and solvents (and their concentration-dependence) in both free solution and in polyethylene glycol diacrylate (PEG-DA) hydrogels.
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