Journal
HEARING RESEARCH
Volume 237, Issue 1-2, Pages 57-65Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.heares.2007.12.006
Keywords
mimecan/osteoglycin; proteoglycan; hearing loss
Funding
- NEI NIH HHS [R01 EY013395, EY13395] Funding Source: Medline
- NIDCD NIH HHS [R01 DC0188, R01 DC000188, R01 DC003402, R01 DC003402-07, R01 DC004546, R01 DC000188-27, R01 DC04546, R01 DC003402-05, R01 DC003402-08, R01 DC003402-06, P30 DC5209, R01 DC03402, R01 DC003402-04, F32 DC000405, R01 DC003402-03, F31 DC005712, R01 DC006908, R01 DC06908, P30 DC005209, F32 DC00405] Funding Source: Medline
- NIGMS NIH HHS [P01 GM061354] Funding Source: Medline
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Genes involved in the hearing process have been identified through both positional cloning efforts following genetic linkage studies of families with heritable deafness and by candidate gene approaches based on known functional properties or inner ear expression. The latter method of gene discovery may employ a tissue- or organ-specific approach. Through characterization of a human fetal cochlear cDNA library, we have identified transcripts that are preferentially and/or highly expressed in the cochlea. High expression in the cochlea may be suggestive of a fundamental role for a transcript in the auditory system. Herein we report the identification and characterization of a transcript from the cochlear cDNA library with abundant cochlear expression and unknown function that was subsequently determined to represent osteoglycin (OGN). Ogn-deficient mice, when analyzed by auditory brainstem response and distortion product otoacoustic emissions, have normal hearing thresholds. (C) 2007 Elsevier B.V. All rights reserved.
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