Journal
HEARING RESEARCH
Volume 240, Issue 1-2, Pages 80-86Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.heares.2008.03.001
Keywords
otosclerosis; stapes; microarray; gene expression
Funding
- NIDCD NIH HHS [R01 DC005218-01, R01 DC005218, R01 DC005218-05, R01 DC005218-02, R01DC05218, R01 DC005218-03, R01 DC005218-04] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008629] Funding Source: Medline
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Otosclerosis is a complex disease that results in a common form of conductive hearing loss due to impaired mobility of the stapes. Stapedial motion becomes compromised secondary to invasion of otosclerotic foci into the stapedio-vestibular joint. Although environmental factors and genetic causes have been implicated in this process, the pathogenesis of otosclerosis remains poorly understood. To identify molecular contributors to otosclerosis we completed a microarray study of otosclerotic stapedial footplates. Stapes footplate samples from otosclerosis and control patients were used in the analysis. One-hundred-and-ten genes were found to be differentially expressed in otosclerosis samples. Ontological analysis of differentially expressed genes in otosclerosis provides evidence for the involvement of a number of pathways in the disease process that include interleukin signaling, inflammation and signal tramsduction, suggesting that aberrant regulation of these pathways leads to abnormal bone remodeling. Functional analyses of genes from this study will enhance our understanding of the pathogenesis of this disease. (C) 2008 Elsevier B.V. All rights reserved.
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