Journal
HEALTH PHYSICS
Volume 98, Issue 2, Pages 204-208Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HP.0b013e3181abaabf
Keywords
biological indicators; dosimetry; dose assessment; radiation, gamma
Categories
Funding
- Armed Forces Radiobiology Research Institute [BD-10, BD-2]
Ask authors/readers for more resources
Early treatment of populations exposed to ionizing radiation requires accurate and rapid biodosimetry with a precision as high as possible to determine an individual's exposure level and risk for morbidity and mortality. The purpose of this study was to evaluate the utility of multiple blood biomarkers for early-response assessment of radiation exposure using a murine (BALB/c, males) in vivo radiation model. Present results for mice exposed to whole-body Co-60 gamma-rays (0.1 Gy min(-1)) over a broad dose range (0-7 Gy) demonstrate at 24 h after exposure: 1) dose-dependent increase in the acute phase protein serum amyloid A or SAA; 2) dose-dependent changes in blood cell counts (lymphocytes, neutrophils, and ratio of neutrophils to lymphocytes); 3) SAA results coupled with peripheral blood cell counts analyzed with use of multivariate discriminant analysis established very successful separation of irradiated animals; 4) an enhanced separation as the number of biomarkers increased. These results also demonstrate proof-in-concept that plasma protein SAA shows promise as a complimentary approach to conventional biodosimetry for early assessment of radiation exposures and, coupled with peripheral blood cell counts, provides early diagnostic information to effectively manage radiation casualty incidents. Health Phys. 98(2):204-208; 2010
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available