Journal
HEALTH AFFAIRS
Volume 30, Issue 5, Pages 833-841Publisher
PROJECT HOPE
DOI: 10.1377/hlthaff.2011.0078
Keywords
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Funding
- National Institutes of Health [P30CA06516-43]
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Emerging research demonstrates that diet, pollution, and other environmental triggers can alter both the function and expression of human genes and lead to a heightened disease risk. These environment-gene interactions can cause so-called epigenetic changes in gene expression-patterns of which genes are switched on or off-that may account for the rising mortality from chronic diseases in industrialized nations. In this paper, we call for a new transdisciplinary approach to public health that would examine how environmental exposures, both physical and social, influence gene expression and a person's susceptibility to chronic disease. This initiative could lead to new ways to prevent and treat such illnesses.
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