Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 40, Issue 10, Pages 2304-2313Publisher
WILEY
DOI: 10.1002/hed.25381
Keywords
epigenetic(s); epithelial-mesenchymal interactions; gene therapy; therapeutics; nanotechnology; oral carcinogenesis
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Funding
- Strategic Project CNC.IBILI, Portuguese Foundation for Science and Technology, COMPETE/FEDER [FCT: UID/NEU/04539/2013]
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Background Head and neck cancer is the sixth most common cancer worldwide, with oral squamous cell carcinoma (OSCC) being the most representative type. OSCC is a public health problem with high morbidity and poor survival rate. Epithelial-mesenchymal transition is emerging as a hallmark in OSCC. MethodsResultsIn this study, we described the role of microRNAs in epithelial-mesenchymal transition regulation in OSCC based on a PubMed search using articles published in English between January 1, 2010, and January 31, 2018. MicroRNA's regulatory networks seem to be a hallmark of epithelial-mesenchymal transition in OSCC pathophysiology becoming a growing challenge to design new studies and strategies from biology to clinical applications. ConclusionTherefore, we propose that targeting therapies to epithelial-mesenchymal transition-type cells, namely, coordinating microRNAs and/or hydrophobic drugs, such as conventional therapy, could be a promising strategy to improve the outcomes of patients with OSCC.
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