Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 40, Issue 11, Pages 2528-2537Publisher
WILEY
DOI: 10.1002/hed.25385
Keywords
papillary thyroid cancer; propensity score matching; telomerase; telomerase reverse transcriptase (TERT) promoter mutation; transcriptome
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Funding
- Ministry of Science and Technology of Taiwan [MOST-106-2314-B-195-010-MY3]
- MacKay Memorial Hospital [MMH-10715, MMH-E-107-10]
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Background Telomerase reverse transcriptase (TERT) promoter mutations have recently been identified as an important prognostic factor in thyroid cancer. Studies suggest that TERT may have noncanonical functions beyond telomere maintenance. Methods Clinicopathological information and transcriptome data for papillary thyroid carcinoma (PTC) samples were obtained from The Cancer Genome Atlas (TCGA). Propensity score matching was performed to adjust for potential confounding variables between the TERT promoter wild-type group and the mutant group. Gene expression data of 36 patients in the mutant group were systemically compared to those of 72 patients in the wild-type group. Results Tumors with TERT promoter mutations had a higher TERT expression. Pathways central to DNA damage responses and cell cycle regulation were significantly enriched among 888 upregulated genes. Transporter and metabolic activities were overrepresented among 799 downregulated genes. There was no difference in the expression of most of the thyroid differentiation genes. Conclusion The TERT promoter mutations were associated with proliferative and metabolic alterations in PTC.
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