Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 37, Issue 4, Pages 511-517Publisher
WILEY-BLACKWELL
DOI: 10.1002/hed.23629
Keywords
Raman; oral cancer; squamous cell carcinoma (SCC); diagnostics; spectroscopy
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BackgroundCurrent practice for differentiating tissue lesions are based on histopathological criteria. This process is subject to error. The purpose of this study was to test whether an alternative, tissue-based molecular signatures Raman spectra could be used to differentiate premalignant and malignant lesions from normal mucosa or benign lesions. MethodsEighteen treatment naive subjects with histologically diagnosed oral disease were studied by comparing the Raman spectra of lesions with contralateral healthy sites. Principle component and multivariate analysis were used to predict which of the tissue groups the average spectrum of each lesion or normal tissue belonged. ResultsThe average spectra were clearly different between premalignant and malignant lesions and those derived from normal, benign tissues. Premalignant and malignant lesions could be predicted with 100% sensitivity and 77% specificity. ConclusionRaman spectroscopy (RS) offers the potential to provide point of care diagnosis of oral disease using a noninvasive, convenient, and relatively inexpensive technology. (c) 2014 Wiley Periodicals, Inc. Head Neck, 2014 (c) 2014 Wiley Periodicals, Inc. Head Neck37: 511-517, 2015
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