Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 36, Issue 2, Pages 158-163Publisher
WILEY
DOI: 10.1002/hed.23256
Keywords
mucoepidermoid carcinoma; salivary gland carcinoma; parotid gland; survival; lymph node metastases
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Funding
- Yale University School of Medicine
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BackgroundMucoepidermoid carcinoma (MEC) is an uncommon malignancy. To the best of our knowledge, this is the largest study investigating disease-specific survival (DSS) of parotid MEC and the first population-level study of the distribution of nodal metastases. MethodsPatients with MEC of the parotid gland were identified in the Surveillance, Epidemiology, and End Results (SEER) database (1988-2009). ResultsWe identified 2400 patients with MEC: 522 low grade, 1137 intermediate grade, and 741 high grade. Five-year DSS rates for low-grade, intermediate-grade, and high-grade MEC were 98.8%, 97.4%, and 67.0%, respectively (p < .001). Negative prognostic factors included high grade, increasing patient age, and tumor size, extraparenchymal extension, nodal metastases, and distant metastases. High-grade MEC was more likely to have lymph node metastases in levels I to III (34.0%) than low-grade (3.3%) and intermediate-grade MEC (8.1%; p < .001). ConclusionGrade influences the prognosis and distribution of nodal metastases. Results indicate that management guidelines should vary based on grade. (c) 2013 Wiley Periodicals, Inc. Head Neck 36: 158-163, 2014
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