Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 36, Issue 1, Pages 9-14Publisher
WILEY-BLACKWELL
DOI: 10.1002/hed.23263
Keywords
laryngeal cancer; chemotherapy; T lymphocytes; immunity; oropharyngeal cancer
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Funding
- Institute of Cancer/National Institute of Health [P50 CA097248]
- Sinabaldo
- Diane Tozzi Research Fund
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Background. Tumor regression after induction chemotherapy (ICT) identifies laryngeal cancers that are responsive to chemoradiation. Patient immune parameters have recently been associated with response to chemotherapy and may identify responding patients. A retrospective analysis was performed to determine if pretreatment, circulating T lymphocyte levels predicted ICT response in patients with advanced laryngeal cancer.Methods. Pretreatment, circulating T lymphocyte subpopulations were correlated with response to therapy and survival. Results were compared with similar data from an identical phase II trial involving patients with oropharyngeal cancer.Results. An increased percentage of CD4+ cells predicted response to ICT and suggested improved survival in patients with laryngeal, but not oropharyngeal, cancer. In the combined group of patients, increased CD4 levels predicted response to ICT.Conclusion. These findings demonstrate the potential importance of the immune system in chemotherapy response and clinical outcome. Differences in findings between patients with advanced laryngeal and oropharyngeal cancer may reflect different cellular immunity function in the patients with human papillomavirus (HPV)-16+ oropharyngeal cancer. (c) 2013 Wiley Periodicals, Inc. Head Neck36: 9-14, 2014
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