Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 36, Issue 5, Pages 643-651Publisher
WILEY-BLACKWELL
DOI: 10.1002/hed.23343
Keywords
prosthesis; trachea; asymmetrically porous membrane; polycaprolactone; reconstruction
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Funding
- Basic Science Research Program through National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [NRF-2011-0014024]
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Background Congenital and acquired tracheal stenosis continues to be challenging problems. The purpose of this study was to evaluate the efficacy of an asymmetrically porous membrane (APM) to induce tracheal reconstruction by inhibition of granulation tissue growth into the tracheal lumen whereas minimizing graft failure. Methods The APM was fabricated with polycaprolactone (PCL) and pluronic F127 to have nano-size pores at top side, whereas the bottom side had micro-size pores. Fifteen rabbits underwent tracheal defect, which was then reconstructed with the APM. Rabbits were euthanized 1, 4, and 12 weeks postoperatively, and endoscopic, histologic, and radiologic evaluations were conducted. Results Endoscopy did not reveal granulation ingrowth into tracheal lumen. APM was well incorporated into the surrounding tissue on histologic evaluation. CT scans showed well maintained airways. Conclusion Off-the-shelf use of APM for tracheal reconstruction seems to be a promising strategy in the treatment of tracheal defects. (c) 2013 Wiley Periodicals, Inc. Head Neck 36: 643-651, 2014
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