Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 36, Issue 4, Pages 481-486Publisher
WILEY
DOI: 10.1002/hed.23321
Keywords
facial nerve; nerve graft; xenogeneic; acellular nerve; nerve regeneration
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BackgroundBecause of ease of harvest and low immunogenicity, xenogeneic acellular nerve graft (XANG) may be an alternative to autologous nerve to repair facial nerve defects. MethodsFacial nerve defects of Wistar rats were repaired by XANG, and nerve gap regeneration was investigated by electrophysiological test, horseradish peroxidase (HRP) retrograde tracing and histomorphometric analysis, as compared to autograft. ResultsTwenty weeks after the grafting, electrophysiology showed that whisker pad muscles responded to the electrical stimuli given at the site proximal to the transplantation in 2 groups. Some HRP-labeled facial motorneurons were located on the facial nucleus of the operated side, and an abundance of myelinated axons were found at the middle of the grafts and obvious motor endplates in the target muscles in 2 groups, although they were inferior to the contralateral side in numbers. ConclusionXANG represents an alternative approach for the reconstruction of peripheral facial nerve defects. (c) 2013 Wiley Periodicals, Inc. Head Neck36: 481-486, 2014
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