Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 35, Issue 1, Pages 15-22Publisher
WILEY
DOI: 10.1002/hed.22904
Keywords
18F-FDG; PET; CT; tonsil cancer; SUV; metabolic tumor volume; total lesion glycolysis; prognosis prediction
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Funding
- National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea [1120150]
- Samsung Medical Center Clinical Research Development Program, Republic of Korea [CRS-111-17-1]
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Background The prognostic significance of volume-based metabolic parameters measured by 18F-fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT) is not established. We evaluated the prognostic value of metabolic parameters in patients with squamous cell carcinoma (SCC) of the tonsil. Methods We enrolled a total of 69 patients with SCC of the tonsil who underwent pretreatment 18F-FDG PET/CT. We measured maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and asymmetry indices (of SUVmax, MTV, and TLG). The prognostic significance of these parameters and clinical variables was assessed by Cox proportional hazards regression analysis. Results Multivariate analyses with adjustments for age, sex, and American Joint Committee on Cancer stage showed that only TLG (hazard ratio = 1.020, 95% confidence interval 1.0031.037, p = .023) was an independent predictive factor associated with decreased overall survival. Conclusion TLG is a significant independent metabolic prognostic factor for overall survival in patients with SCC of the tonsil. (c) 2012 Wiley Periodicals, Inc. Head Neck, 2013
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