Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 33, Issue 11, Pages 1606-1615Publisher
WILEY-BLACKWELL
DOI: 10.1002/hed.21653
Keywords
squamous cell carcinoma; manganese superoxide dismutase; glutathione peroxidase; oral cancer; prognosis
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Funding
- Veterans General Hospital Kaohsiung, Taiwan [VGHKS97-060, VGHKS97-073, VGHKS98-101, VGHKS99-099]
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Background. We investigated the relationship of the immunohistochemical expression status of manganese superoxide dismutase (MnSOD), catalase, glutathione peroxidase (GPx), and myeloperoxidase (MPO) in buccal mucosal squamous cell carcinoma (SCC) with clinicopathologic parameters and prognosis. Methods. The expression status of MnSOD, GPx, catalase, and MPO was evaluated by immunohistochemistry in a series of 216 surgically resected buccal mucosal SCC specimens, using tissue microarray slides. Results. MnSOD, GPx, catalase, and MPO were commonly expressed in buccal mucosal SCC. The high expression level of MnSOD was associated with better disease-specific survival (p = .009), especially for patients in moderate or poor cell differentiation (p = .045), pathologic stage I (p = .002) and postoperative radiotherapy (p = .048). The high expression level of GPx was also correlated with better disease-specific survival (p = .042), especially for patients in pathologic stage IV (p = .010) and postoperative radiotherapy (p = .018). Conclusions. MnSOD and GPx are significant prognostic factors for favorable survival in patients with buccal mucosal SCC. (C) 2011 Wiley Periodicals, Inc. Head Neck 33: 1606-1615, 2011
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