LEAN BODY MASS GAIN IN PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CANCER TREATED PERIOPERATIVELY WITH A PROTEIN- AND ENERGY-DENSE NUTRITIONAL SUPPLEMENT CONTAINING EICOSAPENTAENOIC ACID

Background. Cancer-associated weight loss may be mediated by an inflammatory response to cancer. Eicosapentaenoic acid (EPA) may suppress this response. Methods. Beginning no later than 2 weeks before surgery, patients with head and neck cancer and with weight loss, who were undergoing major resection with curative intent consumed a protein- and energy-dense nutritional supplement containing EPA from fish oil, in addition to usual diet or tube feed. Results. Thirty-one subjects consumed an average of 1.8 containers/day before surgery and 1.5/day during hospitalization (per container: 300 kilocalories, 16 grams (g) protein, 1.08 g EPA). Seventy percent of subjects maintained or gained weight before hospital admission. Mean weight gain was 0.71 kg at admission and 0.66 kg at discharge. At discharge lean body mass increased by 3.20 kg (p < .001) and fat decreased by 3.19 kg (p < .001). Conclusions. An EPA-containing protein- and energy-dense nutritional supplement may help increase perioperative lean body mass in patients with head and neck cancer-related weight loss. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 1027-1033, 2011