Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 33, Issue 5, Pages 668-672Publisher
WILEY
DOI: 10.1002/hed.21502
Keywords
oral squamous cell carcinoma; locoregional recurrence; Ki-67; survival; prognosis
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Background. Until now prognostic evaluation for patients with oral squamous cell carcinoma (OSCC) remains difficult. Thus, the aim of the present study was to ascertain the value of Ki-67 expression in predicting locoregional recurrence in OSCC. Methods. In a large, homogeneous study population consisting of 166 patients with OSCC exclusively treated with primary surgery, expression of Ki-67 was investigated by immunohistochemistry. Results. We report that high proliferation significantly correlated to a higher risk of locoregional recurrence in stage I OSCC patients (p = .029). Carcinomas with a Ki-67 labeling index above the median showed a mean time to recurrence of 42 months, whereas mean time to recurrence was 55 months for those tumors below the median (p = .017). Conclusions. This study provides the evidence of a predictive value of Ki-67 expression in stage I OSCC. Therefore, Ki-67 expression level could be used to identify a subgroup of surgically treated patients with stage I OSCC who might benefit from treatment intensification. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 668-672, 2011
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