PROSPECTIVE TRIAL TO EVALUATE STAGED NECK DISSECTION OR ELECTIVE NECK RADIOTHERAPY IN PATIENTS WITH CT-STAGED T1-2 NO SQUAMOUS CELL CARCINOMA OF THE ORAL TONGUE

Background. A prospective study was undertaken to evaluate a policy of selective, single-modality elective neck treatment in T1-2, node-negative oral tongue squamous cell carcinoma. Methods. Where the primary tumor showed 1 of the 4 key pathological criteria (greater than 7 mm of muscle invasion, less than 5 mm of resection margin, perineural or lymphovascular invasion), radiotherapy was delivered to the primary site and the at-risk undissected neck. Otherwise patients underwent ipsilateral neck dissection within 4 weeks of initial resection. Prospective quality of life assessments were performed. Results. The study was closed after accrual of 25 patients, because the high locoregionai recurrence rate met early stopping criteria. With a median follow-up of 3.4 years, the locoregional recurrence rate was 23%. The 4-year overall and disease-free survival rates were 71% and 64%, respectively. Conclusion. The poor disease-free survival reflects the need for better prognostic markers and more aggressive treatment in these patients. (C) 2009 Wiley Periodicals, Inc. Head Neck 32: 191-198, 2010