Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 30, Issue 12, Pages 1607-1614Publisher
WILEY
DOI: 10.1002/hed.20920
Keywords
esthesioneuroblastoma; olfactory neuroblastoma; treatment; survival; head and neck neoplasms; surgery; radiotherapy; recurrence
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- Rachel Higgins
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Background. Esthesioneuroblastoma is rare. The aim of the study was to review our experience and to evaluate the staging system and treatment that best correlates with the patient outcome. Methods. Thirty-nine patients were identified between 1972 and 2006. Results. At presentation 10% had cervical metastases. None had distant metastasis. Five were treated with surgery, 2 with chemotherapy, 1 with radiotherapy, and 30 with surgery and radiation. Local disease control was 82.6% at 5 years. Recurrence was seen in 33% with local and regional disease recurrence at 15% and 18%, respectively. The 5- and 1 0-year overall survival rates were 87.9%, and 69.2%, respectively. Dulguerov classification correlated most closely to survival and recurrence. Conclusions. Dulguerov classification best correlates with the patient's outcome, A combined approach is the preferred treatment. It makes no difference whether radiotherapy is given pre or postsurgical resection. Recurrence can occur even 15 years after treatment, Therefore, long-term follow-up is essential, (C) 2008 Wiley Periodicals, Inc. Head Neck 30: 1607-1614, 2008
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