Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 30, Issue 7, Pages 946-963Publisher
WILEY
DOI: 10.1002/hed.20833
Keywords
nasopharyngeal carcinoma (NPC); Epstein-Barr virus (EBV); LMP1; tumorigenesis; review
Categories
Funding
- NCI NIH HHS [R01 CA 093708-01A3, R01 CA093708-01A3, R01 CA093708, R01 CA093708-02, R01 CA093708-04, R01 CA093708-03] Funding Source: Medline
Ask authors/readers for more resources
Nasopharyngeal carcinoma (NPC) is a head and neck cancer rare throughout most of the world but common in certain geographic areas, such as southern Asia. While environmental factors and genetic susceptibility play important roles in NPC pathogenesis, the Epstein-Barr virus in particular has been implicated in the molecular abnormalities leading to NPC. There is upregulation of cellular proliferation pathways such as the Akt pathway, mitogen-activated protein kinases, and the Wnt pathway. Cell adhesion is compromised due to abnormal E-cadherin and beta-catenin function. Aberrations in cell cycle are due to dysregulation of factors such as p 16, cyclin D1, and cyclin E. Anti-apoptotic mechanisms are also upregulated. There are multiple abnormalities unique to NPC that are potential targets for novel treatments. (c) 2008 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available