Journal
HAEMOPHILIA
Volume 20, Issue 6, Pages 831-835Publisher
WILEY
DOI: 10.1111/hae.12503
Keywords
bleeding questionnaire; bleeding score; ISTH-BAT; normal range
Categories
Funding
- Canadian Hemophilia Society
- Zimmerman Program for the Molecular and Clinical Biology of von Willebrand disease - National Institutes of Health Program Project [HL081588]
- National Center for Advancing Translational Sciences (NCATS) [UL1 TR000043]
- National Institutes of Health and Translational Science Award (CTSA)
- C17 Research Network
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Bleeding Assessment Tools (BATs) have been developed to aid in the standardized evaluation of bleeding symptoms. The Vicenza Bleeding Questionnaire (BQ), published in 2005, established a common framework and scoring key that has undergone subsequent modification over the years, culminating in the publication of the ISTH-BAT in 2010. Understanding the normal range of bleeding scores is critical when assessing the utility of a BAT. Within the context of The Merging Project, a bioinformatics system was created to facilitate the merging of legacy data derived from four different (but all Vicenza-based) BATs; the MCMDM1-VWD BQ, the Condensed MCMDM-1VWD BQ, the Pediatric Bleeding Questionnaire and the ISTH-BAT. Data from 1040 normal adults and 328 children were included in the final analysis, which showed that the normal range is 0-3 for adult males, 0-5 for adult females and 0-2 in children for both males and females. Therefore, the cut-off for a positive or abnormal BS is 4 in adult males, 6 in adult females and 3 in children. This information can now be used to objectively assess bleeding symptoms as normal or abnormal in future studies.
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