Synthesis and Investigation of copper(I) complexes with a N3S-thioether ligand system

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Authors

Anna Leah Scholl¹ , Thomas Rotärmel¹ , Siegfried Schindler¹

1. Justus Liebig University

Conference / event

26th annual spring symposium, March 2024 (Ulm, Germany)

Poster summary

Regarding sustainability, a long-lasting research goal has been to perform the aerobic aliphatic C-H oxidation under mild and greener conditions. In nature, some copper-containing enzymes can activate dioxygen and strong C-H bonds to perform these reactions. For example, peptidylglycine α-hydroxylating monooxygenase (PHM) that is involved in the post-translational modification of peptides. The active site of PHM consists of the amino acids histidine and methionine. Until now, the role of the thioether group in catalytic reactions is unclear. Therefore, different ligands with N2S and N3S systems have already been synthesized to mimic the active site of these enzymes, leading to different “copper-oxygen”-species. Based on earlier work, a series of new N3S and N3 ligands (derivatives of tmpa) were analyzed in comparison with known systems. The reactivity of the corresponding copper(I)-complexes with dioxygen was investigated by applying low-temperature UV/Vis and stopped-flow measurements. Bis(mu-oxo)dicopper(III) and trans-1,2-peroxodicopper(II)-species could be identified as reactive intermediates.

Keywords

Dioxygen Activation, Bioinorganic Chemistry, Coordination Chemistry, Copper

Research areas

Chemistry

References

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Funding

No data provided

Supplemental files

No data provided

Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

Creative Commons license

Copyright © 2024 Scholl et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.