77 Views
·
56 Downloads
·
★★★★★ 5.0
Synthesis and Investigation of copper(I) complexes with a N3S-thioether ligand system
PUBLISHED June 03, 2024 (DOI: https://doi.org/10.54985/peeref.2406p8519202)
NOT PEER REVIEWED
-
Authors
-
Anna Leah Scholl1 , Thomas Rotärmel1 , Siegfried Schindler1
- Justus Liebig University
-
Conference / event
- 26th annual spring symposium, March 2024 (Ulm, Germany)
-
Poster summary
- Regarding sustainability, a long-lasting research goal has been to perform the aerobic aliphatic C-H oxidation under mild and greener conditions. In nature, some copper-containing enzymes can activate dioxygen and strong C-H bonds to perform these reactions. For example, peptidylglycine α-hydroxylating monooxygenase (PHM) that is involved in the post-translational modification of peptides. The active site of PHM consists of the amino acids histidine and methionine. Until now, the role of the thioether group in catalytic reactions is unclear. Therefore, different ligands with N2S and N3S systems have already been synthesized to mimic the active site of these enzymes, leading to different “copper-oxygen”-species. Based on earlier work, a series of new N3S and N3 ligands (derivatives of tmpa) were analyzed in comparison with known systems. The reactivity of the corresponding copper(I)-complexes with dioxygen was investigated by applying low-temperature UV/Vis and stopped-flow measurements. Bis(mu-oxo)dicopper(III) and trans-1,2-peroxodicopper(II)-species could be identified as reactive intermediates.
-
Keywords
- Dioxygen Activation, Bioinorganic Chemistry, Coordination Chemistry, Copper
-
Research areas
- Chemistry
-
References
-
- E. Roduner, W. Kaim, B. Sarkar, V. B. Urlacher, J. Pleiss, R. Gläser, W.-D. Einicke, G. A. Sprenger, U. Beifuß, E. Klemm, C. Liebner, H. Hieronymus, S.-F. Hsu, B. Plietker, S. Laschat, ChemCatChem 2013, 5, 82–112
- M. Rolff, F. Tuczek, Angew. Chem. Int. Ed. 2008, 47, 2344–2347.
- C. Würtele, E. Gaoutchenova, K. Harms, M. C. Holthausen, J. Sundermeyer, S. Schindler, Angew. Chem. 2006, 118, 3951–3954.
- V. Gómez-Vidales, I. Castillo, Euro. J. Inorg. Chem. 2022, 2022, ejic.202100728.
- S. Kim, J. W. Ginsbach, A. I. Billah, M. A. Siegler, C. D. Moore, E. I. Solomon, K. D. Karlin, J. Am. Chem. Soc. 2014, 136, 8063–80.
- H. Hayashi, S. Fujinami, S. Nagatomo, S. Ogo, M. Suzuki, A. Uehara, Y. Watanabe, T. Kitagawa, J. Am. Chem. Soc. 2000, 122, 2124–2125.
- L. M. Mirica, X. Ottenwaelder, T. D. P. Stack, Chem. Rev. 2004, 104, 1013–1046.
-
Funding
- No data provided
-
Supplemental files
- No data provided
-
Additional information
-
- Competing interests
- No competing interests were disclosed.
- Data availability statement
- The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.
- Creative Commons license
- Copyright © 2024 Scholl et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Share
Rate
Cite
Scholl, A., Rotärmel, T., Schindler, S. Synthesis and Investigation of copper(I) complexes with a N3S-thioether ligand system [not peer reviewed]. Peeref 2024 (poster).
Copy citation
For conference organizers
Utilize the Peeref poster repository to provide free poster publishing for your next event.
Download our convenient portal entry point and include it in your event page.
Get conference access